What does S1DC mean to the real world?
In the previous post, i had to sift through tons of results to get legit "me" related things.
If you search for "S1DC" in google, you gets tons of deviantart links, and tons of shit about this thing called Dictyostelium myosin s1dc. So, i tried to find out what the hell that is. The answer is far from simple, and all i knew for sure was that it has something to do with biochemistry. i have one specific article that sorta says... something. It more or less references, it doesn't say much solid.
ATPase kinetics of the Dictyostelium discoideum myosin II motor domain.
Kuhlman PA, Bagshaw CR.
Department of Biochemistry, University of Leicester, UK.
Structural characterization of the mode of interaction of nucleotides bound to myosin has relied upon the crystal structure of the Dictyostelium discoideum myosin II motor domain. This fragment, denoted S1dC, lacks the regulatory domain and light chain subunits and may therefore fail to display the normal ATPase activity of the intact myosin molecule. Here we show that the elementary steps of the S1dC ATPase pathway and the effects of actin are similar to those of the complete myosin head fragment. This indicates that truncation at residue E759, with the removal of the light chain binding sites, is not crucial to catalytic activity. In particular, S1dC does not show the anomolous tight binding of ADP displayed by slightly shorter M754 construct reported elsewhere. We also show that the fluorescent analogue Cy3-EDA-ATP is a good substrate for S1dC and demonstrate the use of fluorescence correlation spectroscopy to determine the affinity of Cy3-EDA-ADP using microgram quantities of proteins.
PMID: 9682136 [PubMed - indexed for MEDLINE]
Ok, so most of you skimmed that and read nothing. me too. its boring and makes no sense to me whatsoever. So, i go to Wikipedia to find something about the specific elements of the name.
Wikipedia has some info on Myosin, which apparently is found in muscle fiber, particularlly Myosin II, which deals with muscle contraction. an S1 fragment is a complete head and tail of Myosin II ("Myosins are a large family of motor proteins found in eukaryotic tissues. They are responsible for actin-based motility." - wikipedia)
as i dig deeper into this mystery, i find something... odd. Very strange, and very much lacking some cool scientific thing i can tack to my alias' meaning. However, somehow i'm not surprised that my alias has something to do with... *sigh*, slime. Biochem students must laugh at me when they hear my name. How am i related to slime, you might ask?
DICTYOSTELIUM
which is
Dictyostelid
From Wikipedia, the free encyclopedia
(Redirected from Dictyostelium)
Scientific classification
Kingdom: Protista
Phylum: Amoebozoa
Class: Mycetozoa
Order: Dictyosteliida
The dictyostelids are a group of cellular slime moulds. When food (normally bacteria) is readily available they take the form of individual amoebae, which feed and divide normally. However, when the food supply is exhausted, they aggregate to form a multicellular assembly, called a pseudoplasmodium or slug (not to be confused with slug the animal). The slug has a definite anterior and posterior, responds to light and temperature gradients, and has the ability to migrate. Under the correct circumstances the slug matures forming a fruiting body with a stalk supporting one or more balls of spores. These spores are inactive cells protected by resistant cell walls, and become new amoebae once food is available.
Cool. so i'm a slime mold that basically moves around. Fan fuckin tastic. But hey, the word pseudoplasmodium is damn cool, and worth naming a track after, eh?
I'm sure there are people out there who aren't surprised at all about this. heh.
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